Pyrrolidine
CAS # 123-75-1
Pyrrolidine is a cyclic secondary amine characterized by strong basicity and high chemical reactivity used as a key building block in pharmaceutical, agrochemical, and specialty chemical synthesis.
Description:
Pyrrolidine is a highly reactive, low-molecular-weight cyclic secondary amine widely used as a key building block in pharmaceuticals, agrochemicals, and specialty chemical manufacturing. It is known for its strong basicity, excellent solubility, and predictable reactivity. Pyrrolidine enables efficient synthesis of complex molecules and high-value intermediates.
General Properties:
Molecular Formula: C₄H₉N
Appearance: Colorless to pale yellow liquid
Boiling Point: ~87–89 °C
Solubility: Miscible with water and most organic solvents
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Applications:
Pharmaceutical & API Manufacturing
A critical intermediate in the synthesis of active pharmaceutical ingredients, salts, and fine chemicals where controlled amine functionality is required.
Agrochemical Production
Used in the manufacture of herbicide, insecticide, and fungicide intermediates, supporting efficient and scalable synthesis routes.
Specialty Chemical Intermediates
Applied in the production of dyes, pigments, corrosion inhibitors, and performance additives.
Catalysis & Organic Synthesis
Serves as a base, solvent, or reactant in various organic reactions, including condensations and substitutions.
Research & Custom Synthesis
Widely used in laboratory and pilot-scale chemistry due to its predictable behavior and high reactivity.
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Advantages:
High Reactivity & Strong Basicity: Facilitates fast, efficient chemical transformations and high conversion rates.
Excellent Solubility: Fully miscible with water and many organic solvents, enabling broad formulation flexibility.
Versatile Synthetic Building Block: Compatible with numerous reaction pathways across pharmaceutical and industrial chemistry.
Supports Complex Molecule Development: Enables creation of advanced, high-value compounds used in regulated and specialty markets.
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Safety & Handling Overview:
Pyrrolidine is a flammable and corrosive amine and must be handled using appropriate industrial safety controls.
Flammable liquid and vapor
Causes burns to skin and eyes
Vapors may cause respiratory irritation
Avoid prolonged exposure
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