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Tetrahydrofuran (THF)

CAS # 109-99-9

Tetrahydrofuran (THF) is a fast-evaporating cyclic ether widely used as a solvent and reaction medium in pharmaceutical production, polymer processing, and specialty chemical synthesis.

Description:

Tetrahydrofuran is known for its excellent solvency and complete miscibility with water and many organic solvents, it efficiently dissolves resins, polymers, and organic compounds while supporting precise reaction conditions. Its consistent quality and strong performance make THF a trusted solvent for demanding industrial and laboratory applications.

General Properties:


  • Molecular Formula: C₄H₈O

  • Purity: ≥99.9%

  • Appearance: Clear, colorless liquid

  • Solubility: Completely miscible with water and most organic solvents


Applications:


  • Pharmaceutical & Fine Chemical Manufacturing

    • Used as a high-performance solvent and reaction medium in the synthesis of active pharmaceutical ingredients and specialty intermediates.

  • Polymer & Resin Production

    • A key solvent in the manufacture of polyurethane resins, elastomers, and specialty polymers, including polytetramethylene ether glycol (PTMEG).

  • Coatings, Adhesives & Sealants

    • Improves resin dissolution, viscosity control, and film formation in high-performance coatings and adhesive formulations.

  • Laboratory & Analytical Applications

    • Preferred solvent for research and analytical chemistry due to its purity and strong solvency.

  • Extraction & Chemical Processing

    • Used in specialized extraction and purification processes where strong solvency and rapid evaporation are beneficial.

 

Advantages:


  • High Purity (99.9%): Ensures reliable performance in sensitive reactions and advanced chemical manufacturing.

  • Excellent Solvent Power: Dissolves a wide variety of polymers, resins, and organic compounds.

  • Outstanding Compatibility: Miscible with water and many organic solvents, allowing flexible formulation and processing.

  • Fast Evaporation Rate: Supports efficient drying and processing in coatings and adhesives applications.

 

Safety & Handling:


Tetrahydrofuran is a flammable solvent and should be handled using appropriate industrial safety practices.


  • Highly flammable liquid and vapor

  • Vapors may cause dizziness or irritation

  • Can form peroxides during prolonged storage if not properly stabilized

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